In 2026, the at-home medical testing market has matured into a multi-billion dollar industry that prioritizes convenience, privacy, and clinical-grade accuracy. Whether you are tracking a chronic condition, screening for STIs, or optimizing your fitness through hormone monitoring, the current landscape offers a variety of affordable, CLIA-certified options.
The following guide breaks down the best companies for at-home medical testing based on cost-effectiveness, reliability, and speed.
The Top Five Affordable At-Home Testing Companies
1. Everly well: Best for General Wellness & Variety
Everly well remains the industry leader due to its vast catalog of over 30 different tests and a seamless digital interface.
Average Price: $49 – $250.
Best For: Food sensitivities, metabolism panels, and vitamin levels.
Why It’s Affordable: They offer a Control Membership for about $25–$39/month, which allows you to pick one qualifying test per month at a steep discount. This is ideal for those tracking metrics like Vitamin D or HbA1c over time.
Accuracy: All tests are processed in CLIA-certified labs and reviewed by independent physicians.
2. Lets Get Checked: Best for Clinical Speed and Support
Lets Get Checked stands out for its high-touch medical support. Unlike some budget options, every abnormal result is followed up with a call from a registered nurse.
Average Price: $69 – $249.
Best For: Sexual health (STIs), thyroid panels, and male/female hormone levels.
Why It’s Affordable: They offer significant discounts (often 20–30% off) for first-time buyers and frequently provide “bundle” pricing for STI panels that test for 5–8 infections simultaneously.
Turnaround: Results are typically delivered within 2–5 days via a secure app.
3. Lab corp OnDemand: Best for Professional Accuracy
As the consumer-facing arm of one of the world’s largest clinical laboratories, Lab corp OnDemand offers a hybrid model. You can buy the test online and either collect the sample at home or visit one of their thousands of physical locations.
Average Price: $49 – $219.
Best For: Comprehensive metabolic panels (CMP), CBC, and COVID/Flu kits.
Why It’s Affordable: Since they own the labs, there is no “middleman” markup. Their prices are often the lowest for standard blood work like cholesterol or diabetes screening.
Support: Includes a free physician consultation for atypical results.
4. Sesame: Best for Cash-Pay and Budget Users
Sesame operates as a marketplace rather than a single lab provider. It allows you to shop for lab tests the same way you’d shop for a flight.
Average Price: $25 – $80.
Best For: Basic screenings (Blood sugar, Cholesterol, Kidney function).
Why It’s Affordable: It is designed specifically for the uninsured or those with high-deductible plans. You see the “cash price” upfront, which is often 40–60% lower than what a hospital would bill an insurance company.
5. my LAB Box: Best for Comprehensive STI Screening
For those seeking total privacy in sexual health, my LAB Box offers the most expansive “all-in-one” kits on the market.
Average Price: $79 – $399 (for total panels).
Best For: Multi-panel STI testing and toxicology.
Why It’s Affordable: They provide free telemedicine consultations and can even prescribe medication for certain positive results (like Chlamydia or Gonorrhea) at no extra cost, saving you a second trip to a clinic.
Comparing Popular Test Costs (2026 Averages)
| Test Type | Top Provider | Estimated Cost |
| Basic Thyroid (TSH) | Labcorp OnDemand | $69 |
| Vitamin D | Everlywell | $49 |
| Metabolism Panel | LetsGetChecked | $99 |
| Standard 5-Panel STI | myLAB Box | $149 |
| Food Sensitivity (96 items) | Everlywell | $159 |
| Testosterone (Total) | Sesame / Healthyr | $45 – $69 |
Key Considerations for At-Home Testing
The “Hidden” Savings: HSA/FSA Eligibility
Almost all major at-home testing kits are HSA (Health Savings Account) and FSA (Flexible Spending Account) eligible. Using these pre-tax dollars can effectively lower your out-of-pocket cost by 20–30%, depending on your tax bracket.
CLIA and CAP Certifications
Never buy a medical kit from a company that does not mention CLIA (Clinical Laboratory Improvement Amendments) or CAP (College of American Pathologists). These certifications ensure that the lab meets federal standards for accuracy and reliability.
When to Choose In-Person vs. At-Home
While at-home kits are convenient, they usually rely on a “finger-prick” capillary blood sample. For certain tests (like deep nutritional panels or highly sensitive hormone tracking), a venous draw (blood taken from the vein in your arm) is still the gold standard.
Choose At-Home for: Routine screening, peace of mind, and tracking changes over time.
Choose In-Person for: Diagnosing serious symptoms or when your doctor needs highly precise data for a treatment plan.
Summary of Benefits
Privacy: No awkward conversations or waiting rooms.
Transparency: You know the price before you buy.
Empowerment: You own your data and can share it with your doctor at your discretion.